San Diego Chargers (1-3) at Oakland Raiders (3-1)
These two teams are rivals from the old AFL. Chargers QB Philip Rivers is 14-6 against Oakland, with a 97.9 passer rating over last 9 meetings. … RB Melvin Gordon leads league with 6 rushing TDs, with at least one TD in every game this season. … Raiders rank third in total offense but 32nd (last) in total defense. … They swept season series against the Chargers last year, only the second time that’s happened since 2001. … Raiders WR Michael Crabtree caught career-high 3 TD passes in Week 4, had a TD in both meetings with San Diego last season.
Buffalo Bills (2-2) at Los Angeles Rams (3-1)
Coming off of back-to-back road wins (Arizona, Tampa Bay), Rams play their second home game at LA Memorial Coliseum since returning to LA. Bills secondary coach Tim McDonald is father of Rams safety T.J. McDonald. … Rams head coach Jeff Fisher is 7-1 vs. Buffalo, including win in “Music City Miracle” playoff game at Tennessee that helped propel Titans to Super Bowl XXXIV against St. Louis Rams.
Rams DT Aaron Donald was NFC defensive player of week after 1 ½ sacks, 1 forced fumble vs. Arizona. Rams seeking first 4-game winning streak under Fisher; Bills posted shutout at New England in Week 4.
New York Giants (2-2) At Green Bay Packers (2-1)
Refreshed after a Week 4 bye, Packers face visiting Giants team that’s on short week after Monday loss at Minnesota. Green Bay QB Aaron Rodgers snapped streak of 14 games without a 100 passer rating with 129.3 showing Week 3 against Lions that included 4 TD passes in first half. … Packers lead NFL in run defense and are limiting opponents to 1.8 yards per carry. … After lackluster outing vs. Vikings, Giants hope to revive 4th-ranked passing game against Packers’ 29th-ranked pass defense.